U.S. Route 221, I-26 to SC-290
Location: US-221 and I-26, Spartanburg Cty Reassurance shield after the I-26 junction. Location: US-221 and SC-290, Spartanburg Cty Less than a mile later, we’ll approach highway 290. Location: US-221 and SC-290, Spartanburg Cty Turn right for 290 north towards Duncan. S to SC-101/SC-146, N to SC-215 N to SC-417 E to SC-146, W to SC-296
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